Physostigma phys.

Physostigma venenosum. Leguminosæ.
Triturations of the whole bean.
First mentioned by the missionaries to the western coast of Africa ; in 1846 by Daniel ; in 1855 investigated by Christison ; in 1862 first observations by Frazer on the contraction of the pupil (also by Workman) ; used and abused since by many.

Calabar Bean ; Eserine. Leguminosæ.
A climbing plant, native to Africa.
The alcoholic tincture is prepared from the finely pulverized bean.
Toxicological reports, experiments and provings are numerous. See Allen's Encyclopædia, vol. 7, p. 466 .
CLINICAL AUTHORITIES.
- Mental disorder , Kenyon, Raue's Rec., 1875, p. 32, from Trans. N. Y. S., 1873-4, p. 293 ; Nervous excitability , Nash, Times Ret, 1875, p. 37, from Trans. N. Y. S., 1875, p. 176 ; Cerebro-spinal meningitis , Hale, A. H. O., vol. 10, p. 134 ; Wells, A. H. O., vol. 10, p. 476 ; Myopia (3 cases), Woodyatt Times, Ret., 1877, p. 64 ; Ill effects of blow upon eye , Dudgeon, Org., vol. 3, p. 267, from B. J. H., Jan., 1880 ; Eserine in glaucoma , Cant, Smith, Buzzard, Fitzgerald, Brailey, Snell, T. A. J. H., 1886, p. 423 ; Nervous disorders during dentition , Penfield, T. A. J. H., 1884, p. 256 ; Piles , Swan, Hah. Mo., vol. 9, p. 267 ; Sighing during menses , Fiske, Raue's Rec., 1875, p. 176 ; Neuralgic pains in limbs , Kenyon, Raue's Rec., 1875, p. 246, from Trans. N. Y. S., 1873-4, p. 293 ; Tetanus , Helmuth, Raue's Rec., 1875, p. 250, from Trans. N. Y. S., 1873-4, p. 295.

Uncommon mental activity.

Uncommon mental activity.During climacteric change, after severe mental suffering (lost three children), palpitation of heart ; beats irregular ; some three months ago, at time for return of menstruation, was suddenly taken with a feeling of partial faintness, loss of memory, face very red, eyes congested, violent pain all over and through head, constant disposition to talk, which made her cough, feeling as if stomach were full, even up to pit of throat, belching of wind ; sensation of heart beating hard and furiously, yet its motion could hardly be discovered, and in a few moments a violent tonic spasm, lasting nearly an hour ; every muscle in body rigid, no loss of consciousness ; when passing off roaring in ears, great dyspnœa and excessive soreness of muscles of whole body.
Constant pain and distress on top of head ; feels as if she must lose her mind and become insane or despondent ; constant moaning ; thinks she is a castaway ; insomnia with desire to sleep ; terrible thoughts on awaking ; fears she is crazy or will certainly lose her mind ; weak feeling at stomach ; sighing respiration ; constipation ; stools light-colored ; map-tongue. θ Nervous excitability.
Inability to stop thinking with headache.

Dizziness, with faintness and muscæ volitantes on moving, 1 P. M.

Vertigo : staggers like a drunken man, with constrictive feeling of head, with torpor of body and fear of getting crazy ; with sensation of wavering in brain while walking ; < when walking, reading and going down-stairs ; dimness of sight ; with faintness.

Pain in middle of forehead in one spot above eyes, and over and in left eye a pain, with muscæ volitantes.
Pressure in temples.
Pain through temples, as from pressure of blood to head, with throbbing of arteries on side of neck.
Pain through temples and burning of eyes.
Intense painful pressure in vertex and both temples ; has to lie down.
Pressure in vertex extending over to occiput.
Numbness and peculiar sensation in top of head, especially towards back of head.
Five minutes after taking dose, dull pain in left occipital region.
A feeling of loss of power and sensation in back of head as if head would fall over forward, and the natural supports of head would no longer hold it back.
Congestive headache all forenoon.
Rush of blood to head, with heat and burning of nose, sneezing slight.

Intolerable pain over both orbits.
Dull pressing headache for nearly six months ; comparatively free from it in morning, on rising, but < from least mental exertion, until at night after retiring it is almost unbearable ; with the pain, sleeplessness and inability to stop thinking ; in course of an hour or two passes off suddenly, with a sharp, radiating flash of pain, sometimes starting from occiput and passing forward, at other times from before backward.
Intense painful pressure in vertex and temples ; pressure in vertex extending over to occiput ; pain so severe must lie down.
Heavy headache.
Congestion of brain, with epileptiform attacks.
Cerebro-spinal meningitis ; stage of general tetanic rigidity ; retraction of head ; severe headache, with great heat in head, flushed face ; vomiting when raised up ; respiration hurried and irregular ; pulse 100 ; urine scanty.
Cerebro-spinal meningitis ; primary contraction of pupils, secondary dilatation ; heart's action tumultuous, feeble and irregular.

Numbness of temples and crawling sensation over head.
Between 8 and 9 P. M., a creeping numbness over back of head and all down spine, especially in part between hips.

Eyes feel weak.
Great pressure on eyes ; with muscæ volitantes.
Sore pain in eyes, with flying specks.
The medicine affects the sight very much, producing these spectres constantly : flitting before sight, long snakes or worms, both dark and light ; also waves before eyes, making objects have a tremulous motion, as if it gave same quality of involuntary motion to optic nerve that it does to motor nerves, and made the sight movable.
Objects appear larger and nearer.
Slight sensation of double sight, as if images of objects would be multiplied.
Felt film over eyes and blur ; objects mixed, followed by dull pain over and between eyes.
Dimness of distant vision is followed shortly after by contraction of pupil.
(OBS :) Dimness of vision as a sequela to diphtheritis.
The internal rectus does not do its work rightly, and the axes of eyes do not correspond ; eyes feel weak ; lachrymation, especially of left eye.
Feeling of straining in eyes shortly after effects are produced.
On attempting to look upward, not the least movement was perceptible, showing paralysis of superior rectus and inferior oblique muscles.
In looking downward, the superior oblique muscle, which is governed by the n. trochlearis, alone acted, making a slight rotation around the visual axis, rather than a downward movement.
Complete paralysis of accommodation.
(OBS :) Paralysis of ciliary muscles after long-continued debilitating disease.
Let pupil sluggish, not much dilated ; myopia, and objects seem too large, with left eye ; after a blow on left eyeball.
Pupil permanently dilated, with loss of accommodation, of eight years' standing, after traumatic injury to the cornea.
Pupil was dilated, cornea turned well outward, and on looking towards the right side it could not be brought to centre of palpebral fissure (showing a paralysis of internal rectus muscle).
Occasions contraction of pupil and sympathetically dilatation of pupil of other eye.
In twenty minutes pupil contracted to size of pin's head, with a boy.
Shortsightedness.
Myopia.
The effects last longer on iris than on ciliary muscles.
(OBS :) Where iris has a tendency to protrude through a corneal wound.
Drawing-twisting sensation in eyes.
Sharp, shooting and drawing sensation in right eye.
Eyes are sore and give pain when moved from side to side.
Pain in eyeball.
Symptoms of eyes all morning, with much burning of balls.
Burning of eyeballs.
Burning of eyes and bloodshot appearance of them all forenoon.
Eyes smart ; lids feel sore.
Heavy headache and pain in eyes, with much heat in head and face ; muscæ volitantes both black and light.
(OBS :) Ulceration of margin of cornea, leading to perforation, or even when prolapsus of iris has just occurred.
(OBS :) In cases of retinitis, to diminish the access of light.
Beating, or throbbing and twitching between eyebrows.
Excites salivary and lachrymal secretion.
The whole affection came on suddenly ; about a month before she went to bed well, and on rising next morning found it impossible to open eye. θ Rheumatic attack of ocular muscles.
Endeavoring to open eye, a slight upward movement of lid remained, caused by the musculus orbicularis palpebrarum, governed by facial nerve, relaxing itself still more.
Upper lid of left eye hanging down, outer caruncle lower ; that of right side, complete ptosis.
Considerable tenderness of skin around eye.
Mattery eyes.
Intolerable pain over both orbits.

Felt film over eyes and blur ; objects mixed ; after which dull pain over and between eyes.Eyes feel weak.
Dimness of vision.
Pain after using eyes, muscæ volitantes, flashes of light, twitching of lids and around eyes ; myopia.
Acquired myopia, resulting from ciliary spasm.
Partial blindness, on attempting to write was unable to see a line ; dimness of vision ; nystagmus.
Glaucoma ; may relieve intraocular tension temporarily, if not permanently, by acting upon muscular tissues of vessels ; it causes a contraction in their calibre, or, as is more probable, by drawing iris from angle of anterior chamber the filtration passages are opened and excretion thus accelerated ; should not be substituted for iridectomy, however ; useful when operation must be postponed for some reason, or when tension increases after iridectomy, or in some cases of secondary glaucoma.
Woman, æt. 65, lost right eye by glaucoma ; left lens became cataractous, and preliminary iridectomy was made ; eleven days after patient instilled some Atrop. and brought on an acute attack of glaucoma, which was overcome by use of Eserine.
Man, æt. 29, received a blow of cane on right eye ; glaucoma followed ; Eserine was instilled ; recovery complete and permanent.
Lady, æt. 70 ; on fifth day after a fall became glaucomatous (Eserine).
Lady, æt. 64, suffering from severe neuralgia of supra-orbital nerves, had been treated by Gels., typical symptoms of acute glaucoma were found ; Eserine disks caused immediate improvement and in six weeks complete and permanent recovery.
Acute glaucoma in a woman æt. 35, caused by frequent instillation of strong solution of Atrop. for the testing of refraction.
Causes slight twitching of lids, soon followed by contraction of pupils and spasm of ciliary muscle from its action as an irritant to the oculo-motor nerve (antagonistic to Atrop., which causes dilatation of pupil and paralysis of ciliary muscle by paralyzing filaments of third pair).
After a blow upon inferior and outer part of left eyeball ; pupil sluggish, not much dilated ; could not see objects clearly beyond a distance of four inches from left eye and then they seemed too large.
A woman had a cataractous lens dislocated into anterior chamber by a blow on temple two days previously ; there were conjunctival irritation, much photophobia and lachrymation, with severe throbbing pain in eye and right side of head ; tension of eyeball increased ; lens after some difficulty was removed ; during next twenty-four hours tension remained normal and wound tended to heal kindly ; on second morning following removal of lens complained greatly of pain, which had kept her awake during night and still continued ; upper lid was swollen and œdematous ; borders of cut for a space of two or three lines were hazy and infiltrated, a slight stringy and mucous discharge had occurred and tension of eyeball had again increased ; a solution of Eserine 1/200, one drop every two hours, was instilled into eye, and Eserine[3] every two hours prescribed ; in the course of twenty-four hours the tendency to sloughing had ceased, and a rapid recovery followed.
Prolapsus of iris : from injuries even when whole globe is vascular and irritated and sight impaired ; from sloughing of cornea.
Paresis of accommodation after diphtheria, and in muscular asthenopia.
Astigmatism.
Continued drawing, twisting sensation in eyes.
Sharp shooting and drawing sensation in right eye.
Drawing, twisting sensation in eyes at 3 P.M.
Pain in eyeballs.
Eyes sore and give pain when moved from side to side.
Eyes smart ; lids feel sore.
Internal muscle does not seem to do its work rightly and axis of eyes differs in each ; eyes felt weak, with lachrymation, especially of left, from which be suffered when having usual headaches.
Twitching of lid, combined with spasm of ciliary muscle ; twitching around eyes, patient cannot read without much pain, frontal headache, < from light.
Cannot bear to raise lids.
Profuse lachrymation.

A sensation exactly as if nose was going to bleed, and the peculiar taste which goes with it ; at 2 and 8 P. M.
Twitching in nose, and involuntary expansion of nostrils.
Numbness from between eyes down through nose.
Sneezing.
Burning heat in nose and sensation as if it would bleed ; quivering sensation in teeth as if they were resting on a vibrating board ; at 4 P. M.

Stupid look and a drunken gait.
Involuntary twitching of mouth, also of eyebrows.
Sensation of contraction of whole left side of face, with slight numbness.

Sensation of contraction of whole left side of face.

Smarting of end of tongue.
Tongue became very sore on left side, quite back to root, and it was very hard to move it ; felt as if it was stiff.

Tongue feels sore on tip.
Smarting of end of tongue.

Feeling as if a ball was rising in throat.

Feeling as if a ball were coming up to throat.

Disgust of cold drinks.

Desires, Aversions. Disgust for cold drinks.

After eating : relief of pain in head.

Nausea and vomiting.

Trembling sensation in nerves all down through body, especially at pit of stomach, with motion going up and down in nerves like waves, accompanied by slight nausea and a sensation of faintness.
Nervousness at pit of stomach.
Great pain and soreness in and all around pit of stomach, and all around body in this part before and behind.
Sense of emptiness and weakness at stomach, without hunger ; 3 P. M.

Dyspepsia with great pain immediately after eating.

Soreness around body at waist ; 6 P. M.

Sore pain in bowels, with burning, loose discharge.
Bowels spasmodically contracted.

Pains in womb, as if menses were coming on.
Leucorrhœa.
Leucorrhœa and much weakness at 4 P. M.

With disordered menstruation.
Great muscular prostration, with continual inclination to sigh ; leucorrhœa < by exercising during day, especially about 4 P.M. ; sighing < when leucorrhœa is < ; dread of cold water.
Leucorrhœa profuse, with great weakness ; milk-white, bloody, scanty, stringy.

Yawning and sighing respiration.
Laborious breathing.
Kills by paralyzing nerves, supplying breathing muscles.

Respiration : labored ; yawning and sighing.

Severe pain in left side and entirely unlike any pain in lungs that has ever had.

Power of contraction of heart is increased.
Number of beats of heart sometimes increased, sometimes diminished.
Nervous symptoms, with palpitation of heart and much weakness at pit of stomach.
Heart's action feeble and irregular.
Violent palpitation of heart.
Death by paralysis of muscles of heart.
Blood very fluid.
Pulse frequent.
(OBS :) A weak pulse is considered a contraindication ; hard and rapid, an indication.

Tremor of heart due to emotional disturbance ; violent palpitation.

Inclination to stretch out neck, "to run heat out", from uneasy sensations in back of neck.
Pain at back of neck, with difficulty of turning head around.
In afternoon a peculiar pain across back of neck, at base of brain, as if it was cutting off body from head ; it went right through neck, and seemed to go to back part of throat, which was sore and stiff.
Pains in back between shoulders and a little lower down.
Drawing in back, as if it was too short to allow stooping without pain, and yet difficulty in keeping upright.
Pain all down spine and close to it, on both sides of it.
Pains all down back of neck, especially in most prominent bone there, and on each side of it ; drawing whenever head was turned.
Pain in back on each side of spine, from between shoulder blades to below waist ; pain which made it hard to stoop.
Pain in back, also down arms, with weakness of same ; 2 P. M.
Stiffness and pain going all down spine ; with these pains in back there is an inclination to bend forward, as if hard to sit up straight ; 1 P. M.
The nerves in back of body (the passive nerves or nerves of sensation) it seems to paralyze and numb ; and during this numbing process it causes a good deal of pain, very similar to a pain in a tooth, when its nerve is dying or being killed.
Pain in lower part of back and spine, between hips.
Pain in back between hips and a slight feeling of numbness in region of womb ; 6.30 P. M.

Spinal irritation ; every nerve of spinal origin is irritated under this drug ; pressure of finger between vertebræ causes patient to wince ; rigidity of muscles from meningeal irritation ; trismus ; tetanus ; burning and twinging sensations, referable to spinal column, with numbness of feet and hands and other parts of body ; crampy pains in hands ; sudden jerking of limbs on dropping off to sleep ; muscles of back rigid, even a tetanic condition may ensue.
Congestive state of paralysis of spinal cord, with tetanic spasms ; stiffness of neck, with a feeling of drawing and tension ; back very weak, unable to stand erect ; stiffness and pain down spine, with inclination to bend forward, as if hard to sit up straight ; limbs weary as after great fatigue. θ Myelitis acuta.
On walking feeling of unsteadiness from knees downward so that he must tread carefully, especially when eyes are closed ; must look to see where he is going ; wants a cane to support himself ; stiffness in recti femoris ; languor, flatulence. θ Tabes dorsalis.
The will is strong, but a difficulty lies in the way of carrying out its purpose ; the palsy is commonly preceded by twitching or trembling of muscles ; attacks of partial blindness ; nystagmus ; trembling all over. θ Multiple sclerosis.

Trembling of hands, could hardly sew ; 10.30 A. M.
Tired feeling in arms and difficulty in lifting them.
Numbness of left hand as if asleep.
Numbness in left arm and down ring finger.
Chill and slight numbness in right arm.

Pain in lower limbs.
Pain in outside of knee ; cramps in left foot in evening while in a warm bath.
Pain in left thigh and in both knees after walking only a few steps ; about noon.
A sensation as of a drawing of cords behind leg, under knee, making it hard to walk, especially up-stairs.
Trembling of legs, as if one could not walk straight.
A feeling as if all power was going out of legs and they would give may ; as if the cause of the weakness came from that one spot in back, between hips, and took away all power below that spot, from limbs.

Pain in limbs.
(In sick :) Loss of power in limbs.
On walking, feeling of unsteadiness from knees downward, so that he had to tread carefully, especially when eyes are shut ; feels as if he must look to see where he is going.

Neuralgic pains sometimes in upper arms, again in lower limbs whole length, but more severe from hip to knee, more frequently on right side ; pain dull, grinding, crushing, increasing until it became intolerable ; gradual loss of motion of limbs ; long standing, obstinate constipation ; if pain began at any hour, it always continued until 12 o'clock following, either noon or midnight, and then frequently would entirely cease within ten minutes.

Constant desire to move head from side to side.
Disinclination to move.
Hinders voluntary motion as well as causes involuntary motion.
Motion : cannot move eye upward ; difficulty in moving eye downward ; soreness of eye ; tongue stiff and sore.
Walking : pain in left thigh and knees ; and ascending, drawing as of cords under knee ; unsteadiness from knees down.
Stretching : uneasiness in back of neck >.
Turning : pain at back of neck <.
Bending forward : stiffness and pain down spine >.
Lifting arms : tired feeling.

Position. Motion. Must lie down : pressure in head.
Unable to stand erect : from weakness in back.
Inclination to bend forward, as if hard to sit up straight : myelitis.
When raised : vomiting.
Motion : of eyes from side to side causes pain.
Going down stairs : feeling of wavering in brain.
Walking : feeling of wavering in brain ; feeling of unsteadiness from knees downward.

Shuddering and trembling running down through all nerves of body.
Violent tremblings all over, in the street ; felt for an instant as if he should lose consciousness, and could hardly get home ; riding in a car for twenty minutes did not relieve sensations.
Trembling.
Felt a sudden access of vigor and felt particularly strong ; all the symptoms seemed to come like a reaction.
Loss of voluntary motion without loss of consciousness.
Complete relaxation of whole body, as if every nerve was unstrung, even to the eyes, which felt as if all power to see was going out of them.
Giddiness and faintness without uneasiness.
Paralyses motor nerves, but does not impair sensibility, intelligence and muscular irritability.
Cause of death, true suffocation, never causes paralysis of heart.

Great prostration of muscular system ; progression difficult.
Trembling, dizziness and loss of power in limbs.
Tremors of young persons from emotional or physical disturbances ; staggering gait as if drunk ; feeling of constriction around head and waist ; feeling of weakness as if paralyzed ; passes down from occiput through back to lower extremities, which feel as if asleep ; slight exertion causes great weakness. θ Myelitis.
Paralysis agitans as long as structural lesion has taken place.
Progressive muscular atrophy.
Muscular paralysis.
General paralysis of the insane.
Chorea : of right side, tongue feels as if swollen and paralyzed.
Tetanus in consequence of a slight hurt of palm of hand by a small fragment of glass ; no sleep ; spasms of muscles of jaws so violent that a breath of air caused by a person passing would induce them.
Idiopathic or traumatic tetanus.
Epileptiform convulsions.
Cerebro-spinal meningitis, in the tetanic stage.

Intense sleepiness.
Intensely sleepy in morning ; almost impossible to wake himself up ; feels as if drugged.

Irresistible desire to sleep ; soporific sleep.

Morning ; congestive headache ; eye symptoms ; intensely sleepy.
Afternoon : 1 P. M., dizziness and faintness ; stiffness and pain in arms ; 8-9 P. M., creeping numbness over back of head and down spine ; 2-8 P. M., nose feels like bleeding ; 4 P. M., quivering in teeth ; leucorrhœa and weakness ; 6 P. M., soreness around waist ; pain across back of neck ; 2 P. M., pain in back and down arms, weakness of same ; 6.30 P. M., pain between hips, numbness in womb.
Both days he felt weakest, were particularly cool and bracing.
Felt a perfect horror of cold water.

Morning : headache >.
3 P.M. : drawing twisting sensation in eyes.
4 P.M. : leucorrhœa <.
Night : headache unbearable.
If pain began at any hour it always continued until 12 o'clock following either noon or midnight.

The symptoms subside in the same order ; first derangement of accommodation, then affection of pupil.
The trembling spells come on in fits, and at the least thing that startles.

Alternate : dilatation and contraction of pupils.
Six months : dull pressing headache.
Year's duration : constipation.

Right : shooting and drawing in eye ; ptosis ; chill and numbness in arm ; pupil much dilated ; sight of eye impaired ; pupil small.
Left : pain in eye ; dull pain in occipital region ; lachrymation ; pupil sluggish ; upper lid paralyzed ; contraction of face with numbness ; soreness of tongue with difficult motion ; severe pain in chest ; numbness in arm and hand ; pain in thigh.
Before back : pressure in vertex to occiput.

Right : glaucoma following blow upon eye ; throbbing pain in side of head ; shooting and drawing sensation in eye ; neuralgic pains in limbs < ; chorea.
Left : eye, lens became cataractous ; could not see objects clearly beyond a distance of four inches from eye ; lachrymation < ; contraction of whole side of face.
From before backward : flash of pain in head.

The nervous symptoms came first, being in centre of forehead, and very much at pit of stomach, and going downward ; soreness around middle of body came next, and last of all the pains in back and spine ; these lasted the longest and seemed the most characteristic of all the symptoms ; as if pain was cutting head from body.
Nervous motions through body and arms.
A kind of pain like that caused by stooping over work for a long time, or by long pressure of back against a chair ; as if the nerves were compressed ; as if head would fall forward ; as if nose was going to bleed ; as if a ball would rise in throat.
Shooting : in right eye.
Burning : of eyes ; of nose ; of eyeballs ; in nose ; in bowels.
Drawing : in eyes ; in back ; drawing down back of neck when turning head ; as of cords under knee.
Smarting : of eyes ; of end of tongue.
Straining : in eyes.
Twisting : in eyes.
Cramping : in left foot.
Pressure : in temple ; in vertex ; in vertex to occiput ; on eyes.
Soreness : in eyes ; of lids ; of left side of tongue ; around pit of stomach ; around waist ; in bowels ; and stiffness of throat.
Pain : in middle of forehead ; above eyes ; through temples ; dull, in left occipital region ; headache, in morning ; in eyeball ; around pit of stomach ; in womb ; in left chest ; at back of neck ; in back ; down spine ; down back of neck ; down arms ; between hips ; in lower limbs ; in knee ; in left thigh and both knees.
Beating : between eyebrows.
Throbbing : on side of neck ; between eyebrows.
Twitching : between eyebrows ; in nose ; of mouth and of eyebrows.
Quivering : in teeth.
Trembling : all through body ; of legs.
Discomfort : at back of neck.
Heaviness : in head.
Tenderness : around eye.
Stiffness : of left side of tongue.
Contraction : of left side of face.
Tired : in arms.
Faintness : in street and while in car.
Weakness : of eyes ; at pit of stomach.
Powerlessness : at back of head ; of legs.
Creeping : back of head and down spine.
Crawling : over head.
Unsteadiness : from knees down.
Numbness : in top of head ; of temples ; back of head and down spine ; between eyes down through nose ; of left side of face ; region of womb ; of left arm and hand ; in right arm.
Shuddering : through whole body.

As if stomach were full ; as if she must lose her mind ; as if a ball were coming up throat ; lower extremities as if asleep ; back as if paralyzed ; tongue as if swollen and paralyzed.
Pain : in top of head ; in eyeballs ; in stomach ; down spine.
Intolerable pain : over both orbits.
Violent pain : all over.
Sharp, radiating flash of pain : through head.
Sharp shooting : in right eye.
Throbbing pain : in eye and right side of head.
Intense, painful pressure : in vertex and temples.
Neuralgic pains : sometimes in upper arms, again in lower limbs.
Crampy pains : in hands.
Heavy pain : in head.
Drawing : in right eye ; in neck.
Drawing, twisting : in eyes.
Dull pressing headache.
Dull pain : over and between eyes.
Pressure : in vertex.
Constrictive feeling : of head ; of waist.
Contraction : of whole left side of face.
Tension : in neck.
Smarting : of eyes ; of end of tongue.
Soreness : of muscles of whole body ; of eyes ; of lids ; of tip of tongue.
Heat : in head.
Wavering : in brain.
Distress : on top of head.
Stiffness : of neck ; of spine ; in recti femoris.
Weak feeling : at stomach ; in eyes.
Numbness : of hands and feet and other parts of body.

Touch : soreness around pit of stomach ; soreness around waist, 6 P. M.

Pressure : of finger between vertebræ causes wincing.
Hurt in hand from small piece of glass causes tetanus.
Fall caused glaucoma.
Blow upon eye caused glaucoma.

Girl, æt. 9, pupil of right eye very much dilated ; a small scar on outer edge of cornea.
Woman, æt. 24, sight of right eye impaired, could only distinguish light from darkness.
A woman, æt. 21, paralysis of oculo-motor nerve.
Woman, æt. 57, right pupil only half as large.
Man, æt. 53, paraplegia, pupil contracts to pin's head in size.

Miss K., æt. 17 ; myopia.
Miss M., æt. 22 ; myopia.
Man, æt. 30, student ; myopia.
Lady, æt. 49, passing through climacteric change, after severe mental suffering, having lost three children in last eight years ; mental disturbance.
Mrs. C., æt. 65, medium size, dark complexion, lost two daughters six years ago ; nervous excitability.
Mrs. P., æt. 69 ; neuralgic pains in limbs.
Young lady, after injury to hand by piece of glass ; tetanus.

Antidotes : Atropia and Hydrate of Chloral .
Camphor suspends the symptoms temporarily.
Compatible : Amyl nitr., Conium, Gelsem .
Compare : in eye diseases : Agaricus (Amanita), Caustic., Chamom., Conium, Curare ; in tetanus, Nux vom .

Compare : Agaric . in irritable weakness of accommodative apparatus of eye ; Bellad., Conium, Curare, Gelsem., Passiflora, Solanum .

Nervous children whose pupils alternately dilate and contract and who have much trouble when nursing or taking food, pain coming in stomach as soon as they begin to nurse, but passing off if they continue to nurse. θ Dentition.

Constipation of years duration, from atony of bowels.
Severe piles following childbirth.

Chronic bronchial catarrh, < by talking.

Cough with inability to raise mucus.

Perfect horror of cold water ; disgust for cold drinks.